Klein’s Remdesivir-Nucleobase Synthesis Revisited: Chemoselective Cyanation of Pyrrol-2-carboxaldehyde
نویسندگان
چکیده
4-Aminopyrrolo[2,1-f][1,2,4]triazine is a fundamental raw material in the synthesis of remdesivir, which demand has increased due to tests and potential repositioning this drug against Coronavirus disease 2019 (COVID-19). Here, three chemical steps route for preparation remdesivir’s nucleobase described. Particularly, highly chemoselective cyanation Klein’s successful application monochloramine prepared from commercial bleach as an N-amination reagent are presented.
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ژورنال
عنوان ژورنال: Journal of the Brazilian Chemical Society
سال: 2021
ISSN: ['0103-5053', '1678-4790']
DOI: https://doi.org/10.21577/0103-5053.20210037